| 论文题目: | Wound Dressing From Polyvinyl Alcohol/Chitosan Electrospun Fiber Membrane Loaded With OH-CATH30 Nanoparticles |
| 作者: | Zou P, Lee WH, Gao Z, Qin D, Wang Y, Liu J, Sun T, Gao Y |
| 联系作者: | yyg20062006@126.com |
| 发表年度: | 2020 |
| DOI: | doi: 10.1016/j.carbpol.2019.115786 |
| 摘要: | Novel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs on the release of OH-30 was investigated through high-performance liquid chromatography. The antibacterial activities of NP-30-NFs against Escherichia coli and Staphylococcus aureus were studied by bacterial plate counting. NP-30-NFs containing different concentrations of NPs were applied to mouse skin wounds to determine their effectiveness in promoting wound healing. Results showed that NP-30-NFs exhibited antibacterial properties and promoted skin wound healing |
| 刊物名称: | Carbohydrate Polymers |
| 论文出处: | https://www.sciencedirect.com/science/article/pii/S0144861719314547?via%3Dihub |
| 影响因子: | 6.044(2018年) |
