| 论文题目: | Longitudinal Transcriptome Analyses Show Robust T cell Immunity during Recovery from COVID-19 |
| 作者: | Zheng HY, Xu M, Yang CX, Tian RR, Zhang M, Li JJ, Wang XC, Ding ZL, Li GM, Li XL, He YQ, Dong XQ, Yao YG, Zheng YT |
| 联系作者: | zhengyt@mail.kiz.ac.cn |
| 发表年度: | 2021 |
| DOI: | doi: 10.1038/s41392-020-00457-4 |
| 摘要: | Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease |
| 刊物名称: | Signal Transduction and Targeted Therapy |
| 论文出处: | https://www.nature.com/articles/s41392-020-00457-4 |
| 影响因子: | 13.493(2019年) |
