| 论文题目: | Modification of Maternally Defined H3K4me3 Regulates the Inviability of Interspecific Xenopus Hybrids |
| 作者: | Qi Long, Kai Yan, Chendong Wang, Yanling Wen, Furong Qi, Hui Wang, Peng Shi, Xingguo Liu, Wai-Yee Chan, Xuemei Lu, Hui Zhao |
| 联系作者: | 2023 |
| 发表年度: | xuemeilu@mail.kiz.ac.cn |
| DOI: | doi: 10.1126/sciadv.add8343 |
| 摘要: | Increasing evidence suggests that interspecific hybridization is crucial to speciation. However, chromatin incom-patibility during interspecific hybridization often renders this process. Genomic imbalances such as chromo-somal DNA loss and rearrangements leading to infertility have been commonly noted in hybrids. The mechanism underlying reproductive isolation of interspecific hybridization remains elusive. Here, we identified that modification of maternally defined H3K4me3 in Xenopus laevis and Xenopus tropicalis hybrids determines the different fates of the two types of hybrids as texls with developmental arrest and viable lexts. Transcrip-tomics highlighted that the P53 pathway was overactivated, and the Wnt signaling pathway was suppressed in texls hybrids. Moreover, the lack of maternal H3K4me3 in texls disturbed the balance of gene expression between the L and S subgenomes in this hybrid. Attenuation of p53 can postpone the arrested development of texls. Our study suggests an additional model of reproductive isolation based on modifications of maternally defined H3K4me3. Commons |
| 刊物名称: | Science Advances |
| 论文出处: | https://www.science.org/doi/10.1126/sciadv.add8343 |
| 影响因子: | 13.6(2022IF) |
