| 论文题目: | Genomic Evidence for the Nonpathogenic State in HIV-1-infected Northern Pig-tailed Macaques |
| 作者: | Wei Pang, Yong Shao, Xiao-Lin Zhuang, Ying Lu, Wen-Qiang He, Hong-Yi Zheng, Rong Xi, Ming-Xu Zhang, Xiao-Liang Zhang, Jia-Hao Song, Ren-Rong Tian, Fan Shen, Yi-Hui Li, Zu-Jiang Zhao, Dong-Dong Wu, Yong-Tang Zheng |
| 联系作者: | zhengyt@mail.kiz.ac.cn |
| 发表年度: | 2023 |
| DOI: | doi: 10.1093/molbev/msad101 |
| 摘要: | HIV-1 is a highly host-specific retrovirus that infects humans but not most nonhuman primates. Thus, the lack of a suitable primate model that can be directly infected with HIV-1 hinders HIV-1/AIDS research. In the previous study, we have found that the northern pig-tailed macaques (NPMs) are susceptible to HIV-1 infection but show a nonpathogenic state. In this study, to understand this macaque-HIV-1 interaction, we assembled a de novo genome and longitudinal transcriptome for this species during the course of HIV-1 infection. Using comparative genomic analysis, a positively selected gene, Toll-like receptor 8, was identified with a weak ability to induce an inflammatory response in this macaque. In addition, an interferon-stimulated gene, interferon alpha inducible protein 27, was upregulated in acute HIV-1 infection and acquired an enhanced ability to inhibit HIV-1 replication compared with its human ortholog. These findings coincide with the observation of persistently downregulated immune activation and low viral replication and can partially explain the AIDS-free state in this macaque following HIV-1 infection. This study identified a number of unexplored host genes that may hamper HIV-1 replication and pathogenicity in NPMs and provided new insights into the host defense mechanisms in cross-species infection of HIV-1. This work will facilitate the adoption of NPM as a feasible animal model for HIV-1/AIDS research |
| 刊物名称: | Molecular Biology and Evolution |
| 论文出处: | https://academic.oup.com/mbe/article/40/5/msad101/7150876?login=true |
| 影响因子: | 10.7(2022IF) |
