李鸿丽，博士，副研究员。主要从事树鼩衰老表型评估，树鼩阿尔茨海默病模型构建、有效性评估以及化合物药效评价等工作。迄今为止，发表SCI论文27篇，其中第一作者（包括共同第一作者）论文12篇，包括Nature Communications、Cell Reports、Pharmacological Research、Phytotherapy Research等，先后主持国家自然科学基金青年项目、云南省面上项目，入选“兴滇英才支持计划”青年人才和项目支持。

学习和工作经历

2024.01-至今：中国科学院昆明动物研究所，疾病机理遗传学与进化医学学科组，副研究员

2021.09-2023.12：中国科学院昆明动物研究所，疾病机理遗传学与进化医学学科组，助理研究员

2019.10-2021.06: 美国德州健康科学研究中心休斯顿学院童青春教授实验室，访问学生；

2017.09 -2021.07: 上海中医药大学，中药学专业，博士；    

2014.09 -2017.06: 上海中医药大学，中药学专业，硕士；

2010.09-2014.06: 上海中医药大学，药学专业，学士。

第一作者论文（含共同，按时间顺序）

1. Li Hongli#, Su Cunjin#, Xu Yuanzhong, Ludwig Mette Q., Davis Jon, Tong Qingchun*. An alternative neural basis underlying leptin resistance. Cell Reports, 2025, 44(7):115863.

2. Li Hongli#, Xiang Bo-Lin#, Li Xiao, Li Cong, Li Yu, Miao Ying, Ma Guo-Lan, Ma Yu-Hua, Chen Jia-Qi, Zhang Qing-Yu, Lv Long-Bao, Zheng Ping, Bi Rui*, Yao Yong-Gang*. Cognitive deficits and Alzheimer's disease-like pathologies in the aged Chinese tree shrew. Molecular Neurobiology, 2024, 61(4):1892-1906.

3. Li Hongli#, Xu Yuanzhong#, Jiang Yanyan, Jiang Zhiying, Otiz-Guzman Joshua, Morrill Jessie C, Cai Jing, Mao Zhengmei, Xu Yong, Arenkiel Benjamin R, Huang Cheng*, Tong Qingchun*. The melanocortin action is biased toward protection from weight loss in mice. Nature Communications, 2023, 14(1):2200.

4. Zhou Zhenyu#, Yan Yingxuan#, Li Hongli#, Feng Yaru, Huang Cheng*, Fan Shengjie*. Nomilin and its analogues in citrus fruits: a review of its health promotion effects and potential application in medicine. Molecules, 2023, 28(1):269.

5. Li Hongli#, Gao Min#, Chen Ziyu, Zhou Zhenyu, Li Wei, Zhang Xiaoyang, Jiang Xi, Luo Lingling, Li Fei, Wang Gaorui, Zhang Yu, Huang Xingxu, Zhu Jingning*, Fan Shengjie*, Wu Xiaojun*, Huang Cheng*. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytotherapy Research, 2023, 37(8):3296-3308.

6. Li Hongli#, Wang Fei#, Zhou Zhenyu#, Jiang Xi, Li Fei, Feng Yaru, Liu Chuhe, Zhang Yu, Fan Shengjie, Wu Xiaojun*, Huang Cheng*. Atractylon, a novel dopamine 2 receptor agonist, ameliorates Parkinsonian like motor dysfunctions in MPTP-induced mice. Neurotoxicology, 2022, 89:121-126.

7. Li Hongli#, Feng Yaru#, Chen Ziyu, Jiang Xi, Zhou Zhenyu, Yuan Jinfeng, Li Fei, Zhang Yu, Huang Xingxu, Fan Shengjie*, Wu Xiaojun*, Huang Cheng*. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson’s disease in mice and Caenorhabditis elegans. Pharmacological Research, 2021, 163:105220.

8. Li Hongli, Liu Yalei, Liu Chuhe, Luo Lingling, Yao Yin, Li Fei, Yin Liufang, Xu Lai, Tong Qingchun, Huang Cheng and Fan Shengjie*. Notoginsenoside Fe suppresses diet induced obesity and activates paraventricular hypothalamic neurons. RSC Advances, 2019, 9:1290-1298.

9. Li Hongli, Wang Ping, Huang Fei, Jin Jinmei, Wu Hui, Zhang Beibei, Wang Zhifei, Shi Hailian*, Wu Xiaojun*. Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice. Toxicology and Applied Pharmacology, 2018, 340:58-66.

10. Li Hongli, Jin Jinmei, Yang Chun, Wang Ping, Huang Fei, Wu Hui, Zhang Beibei, Shi Hailian* and Wu Xiaojun*. Isoastragaloside I suppresses LPS-induced tight junction disruption and monocyte adhesion on bEnd.3 cells via an activationg Nrf2 antioxidant defense system. RSC Advances, 2018, 8:464-471.

11. Li Hongli#, Lu Lan#, Wang Xiaoshuang, Qin Liyue, Wang Ping, Qiu Shuiping, Wu Hui, Huang Fei, Zhang Beibei, Shi Hailian*, Wu Xiaojun*. Alteration of gut microbiota and inflammatory cytokine/chemokine profiles in 5-fluorouracil induced intestinal mucositis. Frontiers in Cellular and Infection Microbiology, 2017, 7:455.

12. Li Hongli, Wu Hui, Zhang Beibei, Shi Hailian*, Wu Xiaojun*. MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC-803 cell proliferation and IL-8 secretion in vitro and in vivo. Molecular Medicine Reports, 2016, 14(2):1430-1438.

合作作者论文

1. Zhang Bo#, Zhu Tao#, Zhang Haoran#, Yu Xiaomei#, He Jie, Liu Sijia, Liu Yanjun, Wei Zechen, Hu Chaoen, Zhang Yali, Huang Hongdi, Qiu Minghao, Jin Rui, Li Hongli, Xie Huiheng , Wang Jianhong, Hui Hui, Jie Tian. In vivo multimodal magnetic particle imaging for early detection of ischemic stroke in tree shrews. Molecular Imaging and Biology, 2025, online, doi: 10.1007/s11307-025-02031-2

2. Miao Ying#, Zhao Huan#*, Li Yu-Fei, Sun Yan-Ping, Fang Xin, Bi Rui, Li Hongli, Ma Yu-Hua, Lv Long-Bao, Yao Yong-Gang*, Xue Tian*. Light-at-night negatively affects mood in diurnal primate-like tree shrews via a visual pathway related to the perihabenular nucleus. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(23):e2411280122.

3. Zhao Simeng#, Yang Qiuxiang#, Yu Zehua#, Chu Cenfeng, Dai Shengqi, Li Hongli, Diao Min, Feng Lingyue, Ke Junzi, Xue Yilin, Zhou Qifang, Liu Yan, Ma Hanhui, Lin Chao-Po, Yao Yong-Gang, Zhong Guisheng*. Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness. Neuron, 2025, 113(10):1579-1596.e5.

4. Jiang Zhiying#*, He Michelle, Young Claire, Cai Jing, Xu Yuanzhong, Jiang Yanyan, Li Hongli, Yang Maojie, Tong Qingchun*. Dopaminergic neurons in zona incerta drives appetitive self-grooming. Advanced Science, 2024, 11(36):e2308974.

5. Wei Zechen#, Liu Yanjun, Liu Sijia, Yu Xiaomei, Zhang Haoran, Zhu Tao, Zhang Bo, Zhang Yali, Huang Hongdi, Fan Yang, Li Hongli, Wang Jianhong*, Tian Jie*, Hui Hui*. First nonhuman primate-sized magnetic particle imaging system based on digital-scanned focus field. IEEE Transactions on Instrumentation and Measurement, 2024, 73:5023611. 

6. Yao Yong-Gang*, Lu Li, Ni Rong-Jun, Bi Rui, Chen Ceshi, Chen Jia-Qi, Fuchs Eberhard, Gorbatyuk Marina, Lei Hao, Li Hongli, Liu Chunyu, Lv Long-Bao, Tsukiyama-Kohara Kyoko, Kohara Michinori, Perez-Cruz Claudia, Rainer Gregor, Shan Bao-Ci, Shen Fang, Tang An-Zhou, Wang Jing, Xia Wei, Xia Xueshan, Xu Ling, Yu Dandan, Zhang Feng, Zheng Ping, Zheng Yong-Tang, Zhou Jumin, Zhou Jiang-Ning. Study of tree shrew biology and models: A booming and prosperous field for biomedical research. Zoological Research, 2024, 45(4):877-909.

7. Han Yongli#, Luo Lingling, Li Hongli, Zhang Lijun, Yan Yingxuan, Fang Minglv, Yu Jing, Gao Xiaoyan, Liu Ying, Huang Cheng, Fan Shengjie*. Nomilin and its analogue obacunone alleviate NASH and hepatic fibrosis in mice via enhancing antioxidant and anti-inflammation capacity. Biofactors, 2023, 49(6):1189-1204.

8. Cai Jing#, Jiang Yanyan, Xu Yuanzhong, Jiang Zhiying, Young Claire, Li Hongli, Ortiz-Guzman Joshua, Zhuo Yizhou, Li Yulong, Xu Yong, Arenkiel Benjamin R*, Tong Qingchun*. An excitatory projection from the basal forebrain to the ventral tegmental area underlying anorexia-like phenotypes. Neuron, 2023, 112(3):458-472.e6.

9. Xu Min#, Liu Qianjin#, Bi Rui#, Li Yu, Li Hongli, Kang Wei-Bo, Yan Zhongjiang, Zheng Quanzhen, Sun Chunli, Ye Maosen, Xiang Bo-Lin, Luo Xiong-Jian, Li Ming, Zhang Deng-Feng*, Yao Yong-Gang*. Coexistence of multiple functional variants and genes underlies genetic risk locus 11p11.2 of Alzheimer's disease. Biological Psychiatry, 2023, 94(9):743-759.

10. Fan Shengjie#, Yan Yingxuan#, Xia Ying#, Zhou Zhenyu#, Luo Lingling#, Zhu Mengnan#, Han Yongli, Yao Deqiang, Zhang Lijun, Fang Minglv, Peng Lina, Yu Jing, Liu Ying, Gao Xiaoyan, Guan Huida, Li Hongli, Wang Changhong, Wu Xiaojun, Zhu Huanhu*, Cao Yu*, Huang Cheng*. Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. Nature Communications, 2023, 14(1):3368.

11. Xu Yuanzhong*, Jiang Zhiying, Li Hongli, Cai Jing, Jiang Yanyan, Otiz-Guzman Joshua, Xu Yong, Arenkiel Benjamin R, Tong Qingchun*. Lateral septum as a melanocortin downstream site in obesity development. Cell Reports, 2023, 42(5):112502.

12. Fan Shengjie#, Xu Yuanzhong#, Lu Yungang, Jiang Zhiying, Li Hongli, Morrill Jessie C, Cai Jing, Wu Qi, Xu Yong, Xue Mingshan, Arenkiel Benjamin R, Huang Cheng*, Tong Qingchun*. A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia. Nature Communications, 2021, 12(1):2662.

13. Landry Taylor, Li Peixin, Shookster Daniel, Jiang Zhiying, Li Hongli, Laing Brenton Thomas, Bunner Wyatt, Langton Theodore, Tong Qingchun, Huang Hu*. Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice. Molecular Metabolism, 2021, 44:101136.

14. Liu Chuhe, Li Hongli, Zhou Zhenyu, Li Junxiao, Chen Hui, Liu Yalei, Huang Cheng*, Fan Shengjie*. Protopanaxadiol alleviates obesity in high-fat diet-fed mice via activation of energy-sensing neuron in the paraventricular nucleus of hypothalamus. Biochemical and Biophysical Research Communications, 2019, 13(4):1092-1099.

15. Zhang Wei#, Liu Mei#, Yang Liu, Huang Fei, Lan Yunyi, Li Hongli, Wu Hui, Zhang Beibei, Shi Hailian*, Wu Xiaojun*. P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice. Molecules, 2019, 24(3):561.