在Paul-Gerson-Unna皮肤基因组学课题组，我们开发及运用系统组学分析方法及人工智能算法，利用人群队列产生的生物大数据，构建皮肤等外貌相关表型与基因、环境及其它相关表型的互作网络，建立预测个体健康状况的算法模型。目前有三个研究焦点：  

1. 开发并整合计算方法以定量皮肤及外貌相关表型。  

2. 建模评估基因与环境的互作对皮肤及外貌相关表型的影响。  

3. 探究皮肤及外貌相关表型的在人类进化中所受的适应性选择。

 Sijie Wu#, Manfei Zhang#, Xinzhou Yang#, Fuduan Peng, Juan Zhang, Jingze Tan, Yajun Yang, Lina Wang, Yanan Hu, Qianqian Peng, Jinxi Li, Yu Liu, Yaqun Guan, Chen Chen, Merel A. Hamer, Tamar Nijsten, Changqing Zeng, Kaustubh Adhikari, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Hui Li, Jean Krutmann, Fan Liu, Manfred Kayser, Andres Ruiz-Linares, Kun Tang, Shuhua Xu, Liang Zhang*, Li Jin*, Sijia Wang*, Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLoS Genet, 2018 Sep 24;14(9):e1007640. 

Lu Qiao, Yajun Yang, Pengcheng Fu, Sile Hu, Hang Zhou, Shouneng Peng, Jingze Tan, Yan Lu, Haiyi Lou, Dongsheng Lu, Sijie Wu, Jing Guo, Li Jin, Yaqun Guan,Sijia Wang*, Shuhua Xu*, Kun Tang*, Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction. J Genet Genomics, 2018 Aug 20;45(8):419-432. 

John R. Shaffer#, Jinxi Li#, Myoung Keun Lee, Jasmien Roosenboom, Ekaterina Orlova, Kaustabh Adhikari, 23andMe Research Team, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria Catira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-Jose, Paige E. Pfeffer, Christopher A. Wollenschlaeger, Jacqueline T. Hecht, George L. Wehby, Lina M. Moreno, Anan Ding, Li Jin, Yajun Yang, Jenna C. Carlson, Elizabeth J. Leslie, Eleanor Feingold, Mary L. Marazita, David A. Hinds, Timothy C. Cox, Sijia Wang*, Andres Ruiz-Linares, and Seth M. Weinberg*, Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment. Am J Hum Genet, 2017 Dec 7;101(6):913-924. 

Anan Ding#, Yajun Yang#, Zhuohui Zhao#, Anke Huls, Andrea Vierkotter, Ziyu Yuan, Jing Cai, Juan Zhang, Wenshan Gao, Jinxi Li, Manfei Zhang, Mary Matsui, Jean Krutmann, Haidong Kan, Tamara Schikowski*, Li Jin*, Sijia Wang*, Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep, 2017 Nov 10;7(1):15329. 

Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*, Genetic history of Xinjiang's Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Mol Biol Evol, 2017 Oct 1;34(10):2572-2582. 

Wenshan Gao#, Jingze Tan#, Anke Huls#, Anan Ding, Yu Liu, Mary S. Matsui, Andrea Vierkotter, Jean Krutmann, Tamara Schikowski*, Li Jin*, Sijia Wang*, Genetic variants associated with skin aging in the Chinese Han population. J Dermatol Sci, 2017 Apr;86(1):21-29. 

Manfei Zhang#, Bingjie Li#, Sijie Wu, Jingze Tan, Yajun Yang, Alessandra Marini, Andrea Vierkotter, Juan Zhang, Hui Li, Tamara Schikowski, Li Jin, Jean Krutmann, Sijia Wang*, A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol, 2017 Apr;137(4):979-982. 

Manfei Zhang#, Sijie Wu#, Juan Zhang#, Yajun Yang#, Jingze Tan, Yu Liu, Haijuan Guan, Kun Tang, Jean Krutmann, Shuhua Xu, Li Jin, Yaqun Guan*, Hui Li*, Sijia Wang*, Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics, 2016 Dec 20;43(12):702-704. 

Sijie Wu#, Jingze Tan#, Yajun Yan#, Qianqian Peng, Manfei Zhang, Jinxi Li, Dongsheng Lu, Yu Liu, Haiyi Lou, Qidi Feng, Yan Lu, Yanqun Guan, Zhaoxia Zhang, Yi Jiao, Pardis Sabeti, Jean Krutmann, Kun Tang, Li Jin*, Shuhua Xu*,Sijia Wang*, Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet, 2016 Nov;135(11):1279-1286. 

Anke Huls#, Andrea Vierkotter#, Wenshan Gao#, Ursula Kramer, Yajun Yang, Anan Ding, Sabine Stolz, Mary Matsui, Haiong Kan, Li Jin*, Sijia Wang*, Jean Krutmann*, Tamara Schikowski, Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians. J Invest Dermatol, 2016 May;136(5):1053-6. 

Lian Deng, Andres Ruiz-Linares, Shuhua Xu*, Sijia Wang*, Ancestry variation and footprints of natural selection along the genome in Latin American populations. Sci Rep, 2016 Feb 18;6:21766. 

Qianqian Peng#, Jinxi Li#, Jingze Tan#, Yajun Yang#, Manfei Zhang, Sijie Wu, Yu Liu, Juan Zhang, Pengfei Qin, Yaqun Guan, Yi Jiao, Zhaoxia Zhang, Pardis C. Sabeti, Kun Tang, Shuhua Xu, Li Jin*, Sijia Wang*, EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Hum Genet, 2016 Jan;135(1):99-108. 

Miaozhu Li#, Andrea Vierkotter#, Tamara Schikowski#, Anke Huls, Anan Ding, Mary S. Matsui, Binwei Deng, Chuan Ma, Aiguo Ren, Juan Zhang, Jingze Tan, Yajun Yang, Li Jin, Jean Krutmann*, Zhiwen Li*, Sijia Wang*, Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci, 2015 Aug;79(2):148-54. 

Jingze Tan#, Yanjun Yang#, Kun Tang, Pardis C.Sabeti, Li Jin*, Sijia Wang*, The adaptive variant EDARV370A is associated with straight hair in East Asians. Hum Genet, 2013 Oct;132(10):1187-91. 

Yana G. Kamberov#, Sijia Wang#, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas,Daniel E. Lieberman, Li Jin*, Clifford J. Tabin, Bruce A. Morgan*, Pardis C. Sabeti*, Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell, 2013 Feb 14;152(4):691-702. 

Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M.Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Catira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, Jose E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier*, Andres Ruiz-Linares*, Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet, 2008 Mar 21;4(3):e1000037. 

Sijia Wang#, Cecil M. Lewis Jr#, Mattias Jakobsson#, Sohini Ramachandran, Nicolas Ray, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Guido Mazzotti, Giovanni Poletti, Kim Hill, Ana M.Hurtado, Damian Labuda, William Klitz, Ramiro Barrantes, Maria Catira Bortolini, Francisco M. Salzano, Maria Luiza Petzl-Erler, Luiza T. Tsuneto, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Marcus W. Feldman, Noah A. Rosenberg*, Andres Ruiz-Linares*, Genetic variation and population structure in Native Americans. PLoS Genet, 2007 Nov;3(11):e185.