表观遗传与发育调控 

表观遗传和发育生物学是基因型和表型之间不可缺少的重要研究层面。焦保卫研究员以表观遗传中RNA调控元件（长链非编码RNA和RNA剪接）分析器官发育（乳腺为侧重点）及其病理状态（乳腺癌）下遗传和进化如何贡献于系统发育。其课题组也基于高通量单细胞测序技术分析器官发育中细胞群的异质性和谱系发生规律。 

Wang S^#,Ke H^#,Zhang H,Ma Y,Ao L,Zou L,Yang Q,Zhu H,Nie J^*,Wu C^*,Jiao B^*.2018.LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci.Cell Death Dis. 24;9(8):805. doi: 10.1038/s41419-018-0869-2. 

Chen W^#, Wang H^#, Cheng M, Ni L, Zou L, Yang Q, Cai X,Jiao B^*.2018. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 Signaling.Biomed Pharmacother. 103:435-442. 

Ke H^#, Zhao L^#, Zhang H^#, Feng X, Xu H, Hao J, Wang S, Yang Q, Zou L, Su X, Wang L, Wu C, Wang Y, Nie J,Jiao B^*, 2018.Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3.Proc Natl Acad Sci U S A..115(15):E3426-E3435. 

Zhang H^#, Yang X^#, Feng X, Xu H, Yang Q, Zou L, Yan M, Liu D, Su X,Jiao B^*.2018 .Chromosome-wide gene dosage rebalance may benefit tumor progression.Mol Genet Genomics.    5. doi: 10.1007/s00438-018-1429-2. 

Yang X, Wang H^*,Jiao B^*. 2017. Mammary gland stem cells and their application in breast cancer.Oncotarget. . 8(6):10675-10691. 

Ke H, Zhao L, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L,Jiao B^*.2016.NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548.Gene Regulation and Systems Biology, 10(Suppl 1):11-7. 

Wu Y,Feng X,Gao L,Jiao B^*. Imprinted genes: important regulators in development.Yi Chuan. 2016 Jun 20;38(6):508-522. 

Shin J., Wallingford MC, Gallant J., Marcho C.,Jiao B., Byron M., Bossenz M., Lawrence JB, Jones S., Mager J.& Bach I.         2013.RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast.Nature.511(7507):86-9. 

Jiao B, Güng？r C, Johnsen SA, Peters MA, Taniguchi-Ishigaki N, Chen YW, Riethdorf S, Drung A, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC & Bach I. 2013. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling.Mol Biol Cell.24(19):3085-96 

Jiao B., Ma H., Shokhirev M., Drung A., Yang Q., Shin J., Lu S., Byron M., Kalantry S., Mercurio AM, Lawrence JB, Hoffmann A. and Bach I.. 2012. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells.Cell.. 149:630-41.