脂滴生物学及代谢性疾病灵长类模型 

脂滴（lipid droplets）是重要的细胞器。脂滴与其它细胞器互作，响应细胞内外环境变化，动态调节细胞的脂类代谢和能量平衡，参与生物体的生长、发育、生殖、衰老、抗逆境等。脂滴在脂肪组织和非脂肪组织（如肝脏、心脏和肌肉等）中大量沉积，导致肥胖、糖尿病、脂肪肝、动脉粥样硬化等代谢性疾病。 

我们利用模式生物秀丽线虫、小鼠、以及细胞系等，结合细胞生物学、遗传学、生物化学及分子生物学等方法和技术，重点研究脂滴的起源和增大调控机理，以及不同生理或者病理条件下脂滴和其它细胞器协同互作调控能量代谢平衡机理。同时，构建代谢性疾病（肥胖、脂肪肝和糖尿病）灵长类（猕猴和树鼩）模型，开展发病机制研究及治疗药物的筛选和评价。 

Junlong Wang^#, Shimeng Xu^#, Jing Gao^#, Linqiang Zhang, Zhiguo Zhang, Wenhui Yang, Hu Zhou^*, Pingsheng Liu^*, andBin Liang^*. SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys.Am J Physiol Endocrinol Metab.doi.org/10.1152/ajpendo.00016.2018.(#Equal contribution) 

Jieyu Wu^#,Xue Jiang^#, Yamei Li, Tingting Zhu, Jingjing Zhang,Zhiguo Zhang, Lingqiang Zhang, Yuru Zhang, Yanli Wang,Xiaoju Zou*,BinLiang *.PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation inCaenorhabditis elegans.Nature Communications.2018(#Equal contribution)10.1038/s41467-018-03531-2. 

Baoshen He#, Jingjing Zhang#, Yanli Wang, Yamei Li, Xiaoju Zou*,Bin Liang*. Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 inC. elegans; evidence for differential regulation of SCD.BBA-Molecular and Cell Biology of Lipids.1863 (2018) 235–246(#Equal contribution) 

Zhang JJ, Hao JJ, Zhang YR, Wang YL, Li MY, Miao HL, Zou XJ*,Liang B*. Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism inCaenorhabditis elegans.Journal of Lipid Research.2017 58:(9) 1845-1854.（被选为当期封面文章） 

Haizhen Wang#, Xue Jiang#, Jieyu Wu, Linqiang Zhang, Jingfei Huang, Yuru Zhang, Xiaoju Zou*,Bin Liang*. Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation inCaenorhabditis elegans.Genetics.2016. doi: 10.1534/genetics.116. 186742 (#Equal contribution)(Comments by GENES to GENOMEShttps://genestogenomes.org/how-worms-that-pump-iron-get-fat/) 

Yuru Zhang#, Haizhen Wang# , Jingjing Zhang# ,Ying Hu#, Linqiang Zhang, Xiaoyun Wu, Xiong Su, Tingting Li, Xiaoju Zou*,Bin Liang*. Cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids inCaenorhabditis elegans.BBA-Molecular and Cell Biology of Lipids.2016.1861(4):310-319. doi: 10.1016/j.bbalip.2016.01.009.(#Equal contribution) 

Shi X#, Li J#, Zou X, Greggain J, Rodkaer SV, Faergeman NJ,Liang B*, Watts JL*.(2013).Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase.Journal of Lipid Research.2504–2514.(#Equal contribution) 

Yuru Zhang, Xiaoju zou, Yihong Ding, Haizhen Wang, Xiaoyun Wu,Bin Liang*. (2013).Comparative Genomics and Functional Study of Lipid Metabolic Genes inCaenorhabditis elegans.BMC Genomics.14:164. doi:10.1186/1471-2164-14-164.(Highly accessed) 

Bin Liang,Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze*. (2006)Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses.Cell Metabolism, Dec;4(6):429-440. (Preview onCell Metabolism, 2006 Dec; 4(6):415-417.)