外周感觉神经系统参与和调节生物体的众多重要生理功能和相关疾病的发生发展，如疼痛、瘙痒和炎症等，但是其背后的分子、细胞和神经机制很大程度上并不清楚，阻碍了相关疾病的治疗和药物研发。通过建立疼痛、瘙痒和炎性疾病等动物模型，使用分子生物学、电生理记录、原代神经元培养及活细胞荧光成像、转录组和蛋白质组分析技术以及动物行为学分析，去解析外周神经系统相关疾病的分子机制，寻找疾病治疗的新靶点，在并在此基础上进行活性分子的筛选和药物研发。

 1.Shu Wang* Dan Zhang, Jinsheng Hu, Qi Jia, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang*Jianru Xiao*. A clinical and mechanistic study of topical borneol-induced analgesia. EMBO molecular medicine 2017 Apr 10. (Impact factor 9.547) *第一兼通讯作者 

2.  Deyuan Su, Yin Nian, Fenglei Zhang, Jinsheng Hu, Jianmin Cui, Ming Zhou, Jian Yang*, Shu Wang*. Thiazolidine reacts with thioreactive biomolecules. Free Radical Biology & Medicine 2017 Mar;104:272-279 (Impact factor 5.784)  *通讯作者 

3.  Minghui Li, Wei K Zhang, Nicole M Benvin, Xiaoyuan Zhou, Deyuan Su, Huan Li, Shu Wang, Ioannis E Michailidis, Liang Tong, Xueming Li & Jian Yang. Structural basis of dual Ca²⁺/pH regulation of the endolysosomal TRPML1 channel. Nature Structural & Molecular Biology  2017 Mar;24(3):205-213. (Impact factor 13.338) 

4.  Minghui Li^#, Xiaoyuan Zhou^#, Shu Wang^#, IoannisMichailidis, Ye Gong, Deyuan Su, Huan Li, Xueming Li & Jian Yang. Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature 2017 Feb 2;542(7639):60-65. (Impact factor 38.138)  ^#共同第一作者 

5.  Deyuan Su, Hong Zhao, Jinsheng Hu, Dan Tang, Jianmin Cui, Ming Zhou, Jian Yang*, Shu Wang*. TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy. EMBO Reports 2016 Oct;17(10):1422-1430. (Impact factor 7.739) *通讯作者 

6.  Shu Wang, Huai-hu Chuang. C-terminal Dimerization Activates the Nociceptive Transduction Channel Transient Receptor Potential Vanilloid 1. Journal of Biological Chemistry 2011 Nov 25; 286(47): 40601–40607. (Impact factor 4.773) 

7.  Elaine Wang^#, Hui Li^#, Shu Wang^#, Alexander Y Chuang, and Huai-huChuang.Induction of TRPV1 desensitization by a biased receptor agonist. Channels (Austin) 2011 Nov-Dec;5(6):464-7. (Impact factor 2.140)  ^#共同第一作者 

8.  Ahmed, Shu Wang, Huai-Hu Chuang, and Robert Oswald. Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations. Journal of Biological Chemistry 2011 Oct 7;286(40):35257-66. (Impact factor 4.773) 

9.  Hui Li^#, Shu Wang^#, Alexander Y. Chuang, Bruce E. Cohen, and Huai-hu Chuang. Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Proceedings of the National Academy of Sciences. 2011 May 17;108(20):8497-502 (Impact factor 9.423)  ^#共同第一作者 

10.   Shu Wang, Kinning Poon, Robert Oswald, and Huai-hu Chuang.Distinct Modulations of Human Capsaicin Receptor by Protons and Magnesium through Different Domains. Journal of Biological Chemistry  2010 Apr 9; 285(15): 11547–11556. (Impact factor 5.328) 

11.   Shu Wang, Tai-Ran Xing, Ming-Liang Tang, Wu Yong, Chen-Chen Li, Di-Yun Ruan. Effects of Cd²⁺ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons. Naunyn-Schmiedeberg Archives of Pharmacology 2008 May;377(3):245-53. (Impact factor 2.830) 

12.   Shu Wang, Pu Hu, Hui-Li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Effects of Cd²⁺ on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area. Toxicology Letters 2008 Feb 15;176(3):215-22. (Impact factor 3.249) 

13.   Shu Wang, Yan Gu, Hui-Li Wang, Xin-Mei Li, Ming Wang, Li-Guang Sun, Di-Yun Ruan. Inhibitory effect of Cd²⁺ on glycine-induced chloride current in rat hippocampal neurons. Brain Research Bulletin 2006 May 31;69(6):680-6. (Impact factor 1.684) 

14.   Hao Sun, Hui-Li Wang, Shu Wang*. d-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro. Neuroscience Letter 2007 Mar 1; 417(2): 118-22. (Impact factor 2.085)  *通讯作者 

15.   Wu Yong, Min-Min Zhang, Shu Wang, Di-Yun Ruan. Effects of sodium valproate on synaptic transmission and neuronal excitability in rat hippocampus. Clinical and Experimental Pharmacology and Physiology 2009 Nov;36(11):1062-7. (Impact factor 1.936)